50mg · 30-count · Mental Health · Brand: Zoloft · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.80 | $3.80 |
| Walmart | $4.00 | $4.00 |
| Kroger | $5.00 | $5.00 |
| Target | $5.50 | $5.50 |
| Rite Aid | $14.50 | $14.50 |
| CVS | $14.99 | $14.99 |
| Walgreens | $15.50 | $15.50 |
The generic form of Sertraline (Sertraline HCl) contains the same active ingredient and is bioequivalent to the brand. Ask your pharmacist to dispense the generic — it works the same way at a fraction of the cost.
Tip: In most states, pharmacists can substitute a generic unless your prescriber writes "dispense as written" (DAW).
Sertraline is prescribed to treat depression, anxiety, and related mood disorders. It is sold under the brand name Zoloft and is available as the generic Sertraline HCl. A standard supply is 30 50mg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Antidepressants and antipsychotics vary widely in price. Most SSRIs and SNRIs have affordable generics, while newer branded medications can cost hundreds per month.
Shop around. The cheapest pharmacy (Costco at $3.80) charges significantly less than the most expensive option ($15.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Zoloft, ask your pharmacist whether the generic Sertraline HCl is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Sertraline is around $3.30.
Coverage depends on your specific plan and formulary. Most mental health medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare.
Prices represent estimated retail cash prices for Sertraline 50mg (30-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Sertraline cost without insurance?
Without insurance, Sertraline 50mg (30-count) ranges from $3.80 at Costco to $15.50. With a GoodRx discount card, the price can be as low as $3.30.
Where is the cheapest place to fill Sertraline?
Costco currently offers the lowest cash price at $3.80 for 30 50mg.
Is there a generic for Sertraline?
Yes — the generic Sertraline HCl is available and bioequivalent to Zoloft. Ask your pharmacist to dispense the generic to save money.
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