DS · 14-count · Antibiotics · Brand: Bactrim · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.50 | $7.50 |
| Walmart | $4.00 | $8.57 |
| Kroger | $4.50 | $9.64 |
| Target | $5.25 | $11.25 |
| Rite Aid | $12.50 | $26.79 |
| CVS | $12.99 | $27.84 |
| Walgreens | $13.50 | $28.93 |
The generic form of Trimethoprim-Sulfa (SMX-TMP) contains the same active ingredient and is bioequivalent to the brand. Ask your pharmacist to dispense the generic — it works the same way at a fraction of the cost.
Tip: In most states, pharmacists can substitute a generic unless your prescriber writes "dispense as written" (DAW).
Trimethoprim-Sulfa is a prescription antibiotic used to treat bacterial infections. It is sold under the brand name Bactrim and is available as the generic SMX-TMP. A standard supply is 14 DS.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Antibiotics are typically short-course prescriptions. Most common antibiotics are available as generics at very low cash prices — many are on Walmart's $4 generic program.
Shop around. The cheapest pharmacy (Costco at $3.50) charges significantly less than the most expensive option ($13.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Bactrim, ask your pharmacist whether the generic SMX-TMP is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Trimethoprim-Sulfa is around $3.00.
Coverage depends on your specific plan and formulary. Most antibiotics medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare.
Prices represent estimated retail cash prices for Trimethoprim-Sulfa DS (14-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Trimethoprim-Sulfa cost without insurance?
Without insurance, Trimethoprim-Sulfa DS (14-count) ranges from $3.50 at Costco to $13.50. With a GoodRx discount card, the price can be as low as $3.00.
Where is the cheapest place to fill Trimethoprim-Sulfa?
Costco currently offers the lowest cash price at $3.50 for 14 DS.
Is there a generic for Trimethoprim-Sulfa?
Yes — the generic SMX-TMP is available and bioequivalent to Bactrim. Ask your pharmacist to dispense the generic to save money.
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