500mg · 21-count · Antibiotics · Brand: Amoxil · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.60 | $5.14 |
| Walmart | $4.00 | $5.71 |
| Kroger | $4.50 | $6.43 |
| Target | $5.00 | $7.14 |
| Rite Aid | $11.50 | $16.43 |
| CVS | $11.99 | $17.13 |
| Walgreens | $12.50 | $17.86 |
Amoxicillin is a prescription antibiotic used to treat bacterial infections. It is sold under the brand name Amoxil and is available as the generic Amoxicillin. A standard supply is 21 500mg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Antibiotics are typically short-course prescriptions. Most common antibiotics are available as generics at very low cash prices — many are on Walmart's $4 generic program.
Amoxicillin belongs to a class of medications called penicillins. It's used to treat a range of bacterial infections and is typically prescribed for a short, defined course rather than ongoing daily use — which is part of why it's sold in smaller counts (like the 21-count supply shown above) instead of a 30-day bottle. Penicillin-class antibiotics are not effective against viral infections, so it's only prescribed when a bacterial cause is suspected or confirmed.
Shop around. The cheapest pharmacy (Costco at $3.60) charges significantly less than the most expensive option ($12.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Amoxil, ask your pharmacist whether the generic Amoxicillin is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Amoxicillin is around $3.20.
As one of the oldest and most widely used antibiotic classes, amoxicillin has no brand-name manufacturer copay card — it's a low-cost generic at essentially every pharmacy, and price differences you see here reflect pharmacy markup rather than any brand-vs-generic gap.
Coverage depends on your specific plan and formulary. Most antibiotics medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Prior authorization is essentially never required for amoxicillin given its decades-long generic status and its role as a first-line antibiotic — if a fill is being delayed, it's far more likely a supply or dosing question than a coverage issue.
Prices represent estimated retail cash prices for Amoxicillin 500mg (21-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Amoxicillin cost without insurance?
Without insurance, Amoxicillin 500mg (21-count) ranges from $3.60 at Costco to $12.50. With a GoodRx discount card, the price can be as low as $3.20.
Where is the cheapest place to fill Amoxicillin?
Costco typically offers the lowest cash price at $3.60 for 21 500mg.
Is there a generic for Amoxicillin?
Yes — the generic Amoxicillin is available and bioequivalent to Amoxil. Ask your pharmacist to dispense the generic to save money.
What if my insurance doesn't cover Amoxicillin at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Amoxicillin cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
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