20mg · 30-count · Mental Health · Brand: Prozac · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.60 | $3.60 |
| Walmart | $4.00 | $4.00 |
| Kroger | $4.50 | $4.50 |
| Target | $5.25 | $5.25 |
| Rite Aid | $13.50 | $13.50 |
| CVS | $13.99 | $13.99 |
| Walgreens | $14.50 | $14.50 |
The generic form of Fluoxetine (Fluoxetine HCl) contains the same active ingredient and is bioequivalent to the brand. Ask your pharmacist to dispense the generic — it works the same way at a fraction of the cost.
Tip: In most states, pharmacists can substitute a generic unless your prescriber writes "dispense as written" (DAW).
Fluoxetine is prescribed to treat depression, anxiety, and related mood disorders. It is sold under the brand name Prozac and is available as the generic Fluoxetine HCl. A standard supply is 30 20mg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Antidepressants and antipsychotics vary widely in price. Most SSRIs and SNRIs have affordable generics, while newer branded medications can cost hundreds per month.
Fluoxetine belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). It was the first SSRI widely marketed and remains one of the most prescribed. Like other SSRIs, it typically takes several weeks of consistent use to reach full effect and shouldn't be stopped abruptly without a prescriber's guidance.
Shop around. The cheapest pharmacy (Costco at $3.60) charges significantly less than the most expensive option ($14.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Prozac, ask your pharmacist whether the generic Fluoxetine HCl is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Fluoxetine is around $3.10.
Fluoxetine has been generic for over two decades and is one of the least expensive SSRIs available, so there's no manufacturer copay card involved — the cash prices above already reflect standard generic-tier pricing.
Coverage depends on your specific plan and formulary. Most mental health medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Prior authorization is uncommon for fluoxetine given its long generic history as a first-line SSRI, which most insurance formularies place on their lowest cost-sharing tier.
Prices represent estimated retail cash prices for Fluoxetine 20mg (30-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Fluoxetine cost without insurance?
Without insurance, Fluoxetine 20mg (30-count) ranges from $3.60 at Costco to $14.50. With a GoodRx discount card, the price can be as low as $3.10.
Where is the cheapest place to fill Fluoxetine?
Costco typically offers the lowest cash price at $3.60 for 30 20mg.
Is there a generic for Fluoxetine?
Yes — the generic Fluoxetine HCl is available and bioequivalent to Prozac. Ask your pharmacist to dispense the generic to save money.
What if my insurance doesn't cover Fluoxetine at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Fluoxetine cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
Compare All Drug Prices
Use our full tool to compare 100+ medications across 7 pharmacy chains.
Compare All Drugs →