250/50mcg · 1-count · Asthma · Brand: Advair Diskus
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $272.00 | $8160.00 |
| Walmart | $298.00 | $8940.00 |
| Target | $300.00 | $9000.00 |
| Kroger | $305.00 | $9150.00 |
| CVS | $319.99 | $9599.70 |
| Rite Aid | $322.00 | $9660.00 |
| Walgreens | $328.00 | $9840.00 |
Fluticasone-Salmeterol is prescribed to treat asthma and other respiratory conditions. It is sold under the brand name Advair Diskus. A standard supply is 1 250/50mcg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Inhaler prices have been a major drug pricing focus. Generic inhalers are now available for some formulations, offering meaningful savings over brand-name options.
Fluticasone-salmeterol (sold under the brand name Advair Diskus) is a combination inhaler that pairs an inhaled corticosteroid (fluticasone) with a long-acting beta-agonist (salmeterol). The corticosteroid component reduces airway inflammation over time, while the long-acting beta-agonist helps keep airways open — which is why this combination is typically prescribed for daily maintenance rather than for sudden symptom relief during a flare-up.
Shop around. The cheapest pharmacy (Costco at $272.00) charges significantly less than the most expensive option ($328.00). A quick call can save you real money.
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Fluticasone-Salmeterol is around $195.00.
Manufacturers of brand-name combination inhalers like Advair Diskus frequently run their own copay assistance or savings-card programs for patients with commercial insurance, which can bring the out-of-pocket cost well below both the cash price and a standard copay. These programs are almost always limited to people with private or employer-sponsored coverage — patients on Medicare or Medicaid typically don't qualify, due to federal rules governing government health programs. Check the manufacturer's official website or ask your prescribing doctor's office whether a current savings card exists, since eligibility and card values change and RxCostCheck doesn't track them here.
Coverage depends on your specific plan and formulary. Most asthma medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Combination maintenance inhalers like this one sometimes require prior authorization or step therapy — meaning your plan may want documentation that you tried a lower-cost inhaler first — particularly if a formulary-preferred alternative exists for your diagnosis.
Prices represent estimated retail cash prices for Fluticasone-Salmeterol 250/50mcg (1-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Fluticasone-Salmeterol cost without insurance?
Without insurance, Fluticasone-Salmeterol 250/50mcg (1-count) ranges from $272.00 at Costco to $328.00. With a GoodRx discount card, the price can be as low as $195.00.
Where is the cheapest place to fill Fluticasone-Salmeterol?
Costco typically offers the lowest cash price at $272.00 for 1 250/50mcg.
Is there a generic for Fluticasone-Salmeterol?
As of 2026, Fluticasone-Salmeterol (Advair Diskus) does not have an FDA-approved generic. Ask your doctor about therapeutic alternatives.
What if my insurance doesn't cover Fluticasone-Salmeterol at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Fluticasone-Salmeterol cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
Compare All Drug Prices
Use our full tool to compare 100+ medications across 7 pharmacy chains.
Compare All Drugs →