20mg · 30-count · Acid Reflux · Brand: Prilosec · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Walmart Cheapest | $4.00 | $4.00 |
| Kroger | $4.50 | $4.50 |
| Costco | $5.49 | $5.49 |
| Target | $7.99 | $7.99 |
| Rite Aid | $10.50 | $10.50 |
| CVS | $10.99 | $10.99 |
| Walgreens | $11.50 | $11.50 |
Omeprazole is prescribed to reduce stomach acid production and treat acid reflux, GERD, and ulcers. It is sold under the brand name Prilosec and is available as the generic Omeprazole. A standard supply is 30 20mg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Proton pump inhibitors (PPIs) and H2 blockers are widely used. Generic versions are available and usually cost under $10/month at cash prices.
Omeprazole belongs to a class of medications called proton pump inhibitors, used to reduce stomach acid for conditions like GERD, ulcers, and heartburn. It's available over-the-counter at a standard strength as well as by prescription — compare the OTC cash price against the prescription price above, since for many patients the OTC version is the same medication at a lower cost. Long-term PPI use has been studied for certain risks (including effects on bone and magnesium levels), which is why many prescribers periodically reassess whether ongoing use is still needed.
Shop around. The cheapest pharmacy (Walmart at $4.00) charges significantly less than the most expensive option ($11.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Prilosec, ask your pharmacist whether the generic Omeprazole is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Omeprazole is around $3.20.
Because Omeprazole is a generic medication, manufacturer-sponsored copay savings cards — the kind commonly offered for newer, brand-name drugs — generally aren't available for it. Prilosec's manufacturer typically doesn't offer a savings card once generic competition exists, though it's worth checking their site directly if your prescriber specifically writes for the brand product. For most patients filling the generic, the discount-card and pharmacy membership options described above are the more realistic way to lower cost.
Coverage depends on your specific plan and formulary. Most acid reflux medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Because omeprazole is available over-the-counter, some insurance plans won't cover the prescription version at all, or will require documentation that OTC use wasn't sufficient — ask your pharmacist to compare the OTC and prescription cash prices before filling.
Prices represent estimated retail cash prices for Omeprazole 20mg (30-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Omeprazole cost without insurance?
Without insurance, Omeprazole 20mg (30-count) ranges from $4.00 at Walmart to $11.50. With a GoodRx discount card, the price can be as low as $3.20.
Where is the cheapest place to fill Omeprazole?
Walmart typically offers the lowest cash price at $4.00 for 30 20mg.
Is there a generic for Omeprazole?
Yes — the generic Omeprazole is available and bioequivalent to Prilosec. Ask your pharmacist to dispense the generic to save money.
What if my insurance doesn't cover Omeprazole at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Omeprazole cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
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