4mg · 10-count · Digestive · Brand: Zofran · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.66 | $3.66 |
| Walmart | $4.14 | $4.14 |
| Kroger | $4.70 | $4.70 |
| Target | $5.39 | $5.39 |
| Rite Aid | $14.85 | $14.85 |
| CVS | $15.54 | $15.54 |
| Walgreens | $16.58 | $16.58 |
The generic form of Ondansetron (Ondansetron HCl) contains the same active ingredient and is bioequivalent to the brand. Ask your pharmacist to dispense the generic — it works the same way, typically at a fraction of the brand-name cost.
Tip: In most states, pharmacists can substitute a generic unless your prescriber writes "dispense as written" (DAW).
Ondansetron (4mg) is sold under the brand name Zofran and the generic Ondansetron HCl. A standard supply tracked here is 10 units at 4mg.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge more for the same medication.
Digestive medications range from short courses to long-term daily use, so check whether your prescription is for acute or maintenance therapy.
Ondansetron belongs to a class of medications called 5-HT3 receptor antagonists, used to prevent and treat nausea and vomiting, including from chemotherapy, surgery, and certain illnesses. It works by blocking serotonin receptors involved in triggering the vomiting reflex. It's available in multiple forms (tablets, dissolving tablets, and others) — make sure your pharmacy fills the exact form your prescriber intended.
Shop around. The cheapest pharmacy tracked here (Costco at $3.66) charges meaningfully less than the most expensive option ($16.58). A quick call can save real money.
Ask for the generic. If your doctor prescribed the brand-name Zofran, ask your pharmacist whether a generic is available. In most states, pharmacists can substitute a generic unless the prescriber writes "dispense as written."
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated low price for Ondansetron is around $3.18.
Because Ondansetron is a generic medication, manufacturer-sponsored copay savings cards — the kind commonly offered for newer, brand-name drugs — generally aren't available for it. Zofran's manufacturer typically doesn't offer a savings card once generic competition exists, though it's worth checking their site directly if your prescriber specifically writes for the brand product. For most patients filling the generic, the discount-card and pharmacy membership options described above are the more realistic way to lower cost.
Coverage depends on your specific plan and formulary. Most medications in this category are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Ondansetron is typically covered without prior authorization when prescribed for standard indications, though very high quantities may prompt a plan to request documentation.
Prices shown are estimated retail cash prices modeled from CMS's public NADAC (National Average Drug Acquisition Cost) dataset, cross-referenced against typical major-chain retail markups. Actual prices vary by location and change frequently. RxCostCheck does not collect or sell your health data. Learn more →
How much does Ondansetron cost without insurance?
Without insurance, Ondansetron (4mg) ranges from $3.66 at Costco to $16.58 at Walgreens. With a discount card, the price can be as low as $3.18.
Where is the cheapest place to fill Ondansetron?
Costco typically offers the lowest estimated cash price at $3.66 for 10 4mg.
Is there a generic for Ondansetron?
Yes — the generic Ondansetron HCl is available and bioequivalent to Zofran. Ask your pharmacist to dispense the generic to save money.
What if my insurance doesn't cover Ondansetron at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Ondansetron cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
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