DS · 14-count · Antibiotics · Brand: Bactrim · Generic available
| Pharmacy | Cash Price | Per-30-Day Equiv. |
|---|---|---|
| Costco Cheapest | $3.50 | $7.50 |
| Walmart | $4.00 | $8.57 |
| Kroger | $4.50 | $9.64 |
| Target | $5.25 | $11.25 |
| Rite Aid | $12.50 | $26.79 |
| CVS | $12.99 | $27.84 |
| Walgreens | $13.50 | $28.93 |
The generic form of Trimethoprim-Sulfa (SMX-TMP) contains the same active ingredient and is bioequivalent to the brand. Ask your pharmacist to dispense the generic — it works the same way at a fraction of the cost.
Tip: In most states, pharmacists can substitute a generic unless your prescriber writes "dispense as written" (DAW).
Trimethoprim-Sulfa is a prescription antibiotic used to treat bacterial infections. It is sold under the brand name Bactrim and is available as the generic SMX-TMP. A standard supply is 14 DS.
Pharmacy pricing is not regulated in the United States, so retailers set their own cash prices. Large retailers like Walmart and Costco typically offer lower prices on generics because they use prescriptions as a traffic driver. Chain pharmacies like CVS and Walgreens tend to charge significantly more.
Antibiotics are typically short-course prescriptions. Most common antibiotics are available as generics at very low cash prices — many are on Walmart's $4 generic program.
Trimethoprim-Sulfa belongs to a class of antibiotics combining trimethoprim and sulfamethoxazole, used to treat a range of bacterial infections including UTIs. Because it contains a sulfa drug, it's not appropriate for patients with a sulfa allergy — make sure your prescriber and pharmacist are aware of any drug allergies before this is filled. As with any antibiotic, complete the full prescribed course even if symptoms improve early.
Shop around. The cheapest pharmacy (Costco at $3.50) charges significantly less than the most expensive option ($13.50). A quick call can save you real money.
Ask for the generic. If your doctor prescribed the brand-name Bactrim, ask your pharmacist whether the generic SMX-TMP is available. In most states, pharmacists can substitute a generic unless the prescriber writes 'dispense as written.'
Use a discount card. Services like GoodRx, SingleCare, and WellRx can sometimes negotiate prices lower than retail cash. The estimated GoodRx low for Trimethoprim-Sulfa is around $3.00.
Because Trimethoprim-Sulfa is a generic medication, manufacturer-sponsored copay savings cards — the kind commonly offered for newer, brand-name drugs — generally aren't available for it. Bactrim's manufacturer typically doesn't offer a savings card once generic competition exists, though it's worth checking their site directly if your prescriber specifically writes for the brand product. For most patients filling the generic, the discount-card and pharmacy membership options described above are the more realistic way to lower cost.
Coverage depends on your specific plan and formulary. Most antibiotics medications are covered under standard health insurance, typically in Tier 1 or Tier 2. If your copay is higher than the cash price above, it may be cheaper to pay out of pocket — ask your pharmacist to compare. Short-course antibiotics like this combination are almost never subject to prior authorization and are typically inexpensive generics.
Prices represent estimated retail cash prices for Trimethoprim-Sulfa DS (14-count) as of 2026. Actual prices may vary. RxCostCheck does not collect or sell your health data. Learn more →
How much does Trimethoprim-Sulfa cost without insurance?
Without insurance, Trimethoprim-Sulfa DS (14-count) ranges from $3.50 at Costco to $13.50. With a GoodRx discount card, the price can be as low as $3.00.
Where is the cheapest place to fill Trimethoprim-Sulfa?
Costco typically offers the lowest cash price at $3.50 for 14 DS.
Is there a generic for Trimethoprim-Sulfa?
Yes — the generic SMX-TMP is available and bioequivalent to Bactrim. Ask your pharmacist to dispense the generic to save money.
What if my insurance doesn't cover Trimethoprim-Sulfa at all?
Ask your prescriber whether a covered therapeutic alternative in the same drug class exists, or ask your pharmacist about a formulary exception or medical-necessity appeal — some plans will cover an otherwise-excluded drug once that documentation is on file. In the meantime, the cash and discount-card pricing shown above is usually the fastest fallback.
Does a 90-day supply of Trimethoprim-Sulfa cost less than three 30-day fills?
Often, yes — many pharmacies and insurance plans price a 90-day fill at a lower effective per-dose cost than separate 30-day fills, and some mail-order pharmacy benefits are built specifically around 90-day supplies. Ask your pharmacist or insurer whether a 90-day option is available for this medication before assuming the count shown above is your only choice.
Compare All Drug Prices
Use our full tool to compare 100+ medications across 7 pharmacy chains.
Compare All Drugs →